In this study pertaining to cannabinoids and their potential usage as treatments for obesity and diabetes, CBD was looked at with particular interest in regards to any additional health issues that can come as a result of obesity in sites that have ties to the endocannabinoid system, namely the liver and the heart, however CBD’s impact on other areas were inspected. With regards to each of these areas there were signs of CBD being of benefit to treating specific conditions and diabetes symptoms.
For the liver, CBD showed a positive influence, namely the reduction of intracellular lipid content in the in vitro hepatosteatosis model, possibly by enhancing lipolysis and mitochondrial activity through increased fatty acids oxidation. Simultaneously, the it was observed that CBD enhanced the level of glutathione, adenosine triphosphate, and nicotinamide adenine dinucleotide, which supported the assumption that CBD increases intracellular lipolysis and mitochondrial activity. Additionally, results displayed that CBD attenuates liver steatosis, inflammatory response, oxidative/nitrative stress, and neutrophil infiltration in the liver.
For the heart, tests on human cardiomyocytes subject to a high glucose concentration as well as a mouse model of type 1 diabetic cardiomyopathy were analysed. It was demonstrated that CBD reduced cardiac fibrosis, myocardial oxidative/ nitrative stress, inflammation and cell death in diabetic hearts, as well as finding that CBD attenuated the high glucose-induced enhanced ROS (reactive oxygen species) generation and cell death in human cardiomyocytes.
Many studies indicated that CBD affects both lipid and glucose metabolism through the action on various receptors as well as several metabolites. From the existing data, it can be seen that CBD has the promising potential as a therapeutic agent and might be effective in alleviating the symptoms of insulin resistance, type 2 diabetes and metabolic syndrome.
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